The role of Th17 and Tregs in the development of tolerance and rejection in a murine model of renal allograft rejection

Th17 和 Tregs 在肾同种异体移植排斥小鼠模型耐受和排斥反应发展中的作用

• 批准号: nhmrc : 1055315
• 负责人: Dr Tony Kwan
• 金额: $ 7.34万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-th17-tregs-allograft-rejection/112448
• 关键词: role; Th17; Tregs; development; tolerance

In clinical transplantation, rejection remains the greatest problem in determining both short and long-term patient outcomes. Tolerance, the ability of the body to accept a transplant without immunosuppressive drugs, remains an as yet unattained goal. The aim of this project is to examine the mechanisms by which the initial immune response (innate immunity) affects the development of tolerance or rejection in a mouse model of kidney transplantation.

在临床移植中，排斥反应仍然是决定短期和长期患者结局的最大问题。耐受性，即身体在没有免疫抑制药物的情况下接受移植的能力，仍然是一个尚未实现的目标。本项目的目的是研究在小鼠肾移植模型中，初始免疫应答（先天免疫）影响耐受或排斥发展的机制。