Regulation and mechanism of nitric oxide synthase isozymes

一氧化氮合酶同工酶的调控及机制

• 批准号: 183521-2007
• 负责人: Guillemette, Guy
• 金额: $ 4.74万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=392144
• 关键词: Regulation; mechanism; nitric; oxide; synthase

Nitric oxide (NO) is one of the most widespread signaling molecules in mammals and important in controlling nearly every cellular and organ function in the body. Since NO plays multiple physiological roles in regulating varied and diverse organ functions, defects in NO production are also involved in a number of pathophysiological states including atherosclerosis, hypertension, stroke and vascular complications in diabetes. NO is synthesized in the body by enzymes named nitric oxide synthases or NOS. NOS enzymes are some of the most complex enzymes ever discovered. Precise control of NOS enzymes is of potential therapeutic value since NO has diverse biological functions and is also a key part of several serious disease states. A significant number of fundamental questions about NOS need to be answered before we can take full advantage of the therapeutic potential of this target enzyme. The long-term goals of our research program are to understand the regulation and mechanism of NOS enzymes and the role of NO in cell function, signalling and differentiation.

一氧化氮(NO)是哺乳动物体内分布最广泛的信号分子之一，在控制体内几乎所有细胞和器官功能方面发挥着重要作用。由于NO在调节多种器官功能方面发挥着多方面的生理作用，NO的产生缺陷也参与了许多病理生理状态，包括动脉粥样硬化、高血压、中风和糖尿病的血管并发症。一氧化氮在体内由称为一氧化氮合酶或一氧化氮合酶的酶合成。一氧化氮合酶是迄今发现的最复杂的酶之一。由于NO具有多种生物学功能，也是几种严重疾病状态的关键部分，因此精确控制NOS酶具有潜在的治疗价值。在充分利用这种靶标酶的治疗潜力之前，需要回答大量关于一氧化氮合酶的基本问题。我们研究计划的长期目标是了解一氧化氮合酶的调节和机制，以及一氧化氮在细胞功能、信号传递和分化中的作用。