S100 proteins: novel oxidant scavengers in allergic inflammation

S100 蛋白：过敏性炎症中的新型氧化剂清除剂

• 批准号: nhmrc : 1027189
• 负责人: A/Pr Nicodemus Tedla
• 金额: $ 33.73万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/s100-proteins-novel-allergic-inflammation/110545
• 关键词: S100; proteins; novel; oxidant; scavengers

Allergic inflammation includes conditions such as dermatitis and asthma. Asthma, affects one in 10 adults and one in 6 Australians, costing ~$720 million/annum. We will characterize new mediators of oxidant defence which have suppressive effects on key pathogenic processes. The novel oxidative changes in S100 proteins may lead to new diagnostic reagents and new strategies for therapy. Results will open new frontiers in asthma biology and will apply to other chronic inflammatory diseases.

过敏性炎症包括皮炎和哮喘。每10个成年人中就有一个人患有哮喘，每6个澳大利亚人中就有一个人患有哮喘，每年的费用约为7.2亿美元。我们将描述对关键致病过程具有抑制作用的新的氧化防御介体。S100蛋白的新氧化变化可能导致新的诊断试剂和新的治疗策略。研究结果将开辟哮喘生物学的新领域，并将适用于其他慢性炎症性疾病。