Regulation of monocyte and macrophage functions by leucocyte immunoglobulin-like receptors (LILRs) in human colon

人结肠中白细胞免疫球蛋白样受体 (LILR) 对单核细胞和巨噬细胞功能的调节

• 批准号: nhmrc : 568771
• 负责人: A/Pr Nicodemus Tedla
• 金额: $ 19.74万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-monocyte-macrophage-human-colon/82747
• 关键词: Regulation; monocyte; macrophage; functions; leucocyte

The human colon contains many bacteria that can invade through a damaged mucosal barrier and provoke immune cells to cause inflammation with their subsequent removal and a rapid shutdown of inflammation. Failure to clear bacteria or inflammation can lead to inflammatory bowel disease or sepsis. We will investigate how new proteins known as Leucocyte Immunoglobulin-like Receptors allow immune cells to effectively clear microorganisms without provoking uncontrolled inflammation

人类结肠含有许多细菌，这些细菌可以通过受损的粘膜屏障侵入并激发免疫细胞引起炎症，随后将其清除并迅速消除炎症。未能清除细菌或炎症可能会导致炎症性肠病或败血症。我们将研究被称为白细胞免疫球蛋白样受体的新蛋白质如何使免疫细胞有效清除微生物而不引发不受控制的炎症