The Role of Pulmonary Macrophages in the Pathogenesis of an Acute Exacerbation of Chronic Asthma

肺巨噬细胞在慢性哮喘急性发作发病机制中的作用

• 批准号: nhmrc : 568616
• 负责人: A/Pr Nicodemus Tedla
• 金额: $ 33.05万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-pulmonary-macrophages-chronic-asthma/98663
• 关键词: Role; Pulmonary; Macrophages; Pathogenesis; Acute

We will examine the role of lung defence cells, known as macrophages, in triggering the inflammation of acute severe asthma. The experimental work will use unique mouse models of mild chronic asthma and of an acute exacerbation of the illness, which have been developed in our laboratories. We will study the mechanisms of activation of the asthmatic response and assess whether treatment with drugs that suppress the function of macrophages can help to control steroid-resistant exacerbations.

我们将研究肺防御细胞（称为巨噬细胞）在触发急性严重哮喘炎症中的作用。实验工作将使用我们实验室开发的独特的轻度慢性哮喘和疾病急性加重的小鼠模型。我们将研究哮喘反应的激活机制，并评估抑制巨噬细胞功能的药物治疗是否有助于控制类固醇耐药加重。