Scabies mite intestinal proteases as targets for novel therapeutics.

疥螨肠道蛋白酶作为新疗法的靶标。

• 批准号: nhmrc : 1067192
• 负责人: Dr Deborah Holt
• 金额: $ 44.84万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/scabies-mite-intestinal-novel-therapeutics/455286
• 关键词: Scabies; mite; intestinal; proteases; targets

Scabies causes bacterial disease affecting poor people worldwide. Available therapies are limited and drug resistance is emerging. We investigate molecules that the mite needs to infest the skin, to guide the formulation and the testing of novel drugs. This will provide improved treatment of affected individuals and their families, thereby reducing the spread of scabies and bacterial infections and their devastating sequelae, particularly in Australian Indigenous communities.

疥疮是一种影响全世界穷人的细菌性疾病。可用的治疗方法有限，耐药性正在出现。我们研究螨虫感染皮肤所需的分子，以指导新药的配方和测试。这将为受影响的个人及其家庭提供更好的治疗，从而减少疥疮和细菌感染的传播及其破坏性后遗症，特别是在澳大利亚土著社区。