Scabies mite proteins as targets for the development of new therapeutics

疥螨蛋白作为开发新疗法的靶标

• 批准号: nhmrc : GNT1054968
• 负责人: Dr Simone Reynolds
• 金额: $ 29.96万
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/scabies-mite-proteins-new-therapeutics/1344584
• 关键词: Scabies; mite; proteins; targets; development

Scabies and associated bacteria disease (pyoderma) are a significant health burden, with pyoderma implicated in rheumatic fever and heart disease. Investigations of the mechanism underlying scabies and bacteria disease links, identified scabies proteins inhibiting the human complement system. The inhibition prevents mite damage and promotes growth of bacteria. This proposal aims to elucidate the interaction between scabies, bacteria and the human host, in order to design new therapeutics.

疥疮和相关细菌性疾病（脓皮病）是严重的健康负担，脓皮病与风湿热和心脏病有关。对疥疮和细菌疾病之间联系的机制的研究发现，疥疮蛋白抑制人类补体系统。这种抑制作用可以防止螨虫损害并促进细菌生长。该提案旨在阐明疥疮、细菌和人类宿主之间的相互作用，以便设计新的疗法。