Scabies mite complement inhibitors as targets for novel therapeutics

疥疮和相关细菌疾病（脓毒症）是一个重大的健康负担，脓毒症与风湿热和心脏病有关。对疥疮和细菌疾病联系的潜在机制的调查，确定了抑制人类补体系统的疥疮蛋白。这种抑制作用可防止螨的损害并促进细菌的生长。该提案旨在阐明疥疮，细菌和人类宿主之间的相互作用，以设计新的治疗方法。

Scabies and associated bacteria disease (pyoderma) are a significant health burden, with pyoderma implicated in rheumatic fever and heart disease. Investigations of the mechanism underlying scabies and bacteria disease links, identified scabies proteins inhibiting the human complement system. The inhibition prevents mite damage and promotes growth of bacteria. This proposal aims to elucidate the interaction between scabies, bacteria and the human host, in order to design new therapeutics.