Next Generation Mass Spectrometry for Single-Cell Metabolomics

单细胞代谢组学的下一代质谱分析

• 批准号: DE240100259
• 负责人: Dr Chang Lei
• 金额: $ 30.83万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE240100259
• 关键词: Next; Generation; Mass; Spectrometry; Single

Characterising metabolites at the single cell level will provide valuable insights into the functionality of individual cells and reveal mechanisms that cannot be observed in bulk cell analysis. To address existing challenges in single-cell metabolite analysis, this project aims to develop an ultra-sensitive nanostructure-initiator mass spectrometry (NIMS) platform, which uses an innovative carbon material with a carefully designed nanostructure to enhance detection efficiency. Expected outcomes include the development of a revolutionary carbon assisted NIMS platform for single-cell metabolomics analysis, and valuable intellectual property of commercial interest to provide economic benefit to Australia through technology advancement.

表征单细胞水平的代谢产物将提供对单个细胞功能的有价值的见解，并揭示在散装细胞分析中无法观察到的机制。为了应对单细胞代谢物分析中的现有挑战，该项目旨在开发超敏感的纳米结构质谱（NIMS）平台，该平台使用具有精心设计的纳米结构的创新碳材料来提高检测效率。预期的结果包括开发革命性的碳辅助NIMS平台进行单细胞代谢组学分析，以及通过技术进步为澳大利亚提供经济利益的宝贵商业利益的知识产权。