Neurophysiology of cerebellar, striatial, and cerebral oscillations and communication for motor execution and learning

小脑、纹状体和大脑振荡的神经生理学以及运动执行和学习的沟通

• 批准号: 261893-2008
• 负责人: Courtemanche, Richard
• 金额: $ 1.46万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=395273
• 关键词: Neurophysiology; cerebellar; striatial; cerebral; oscillations

Many brain functions, if not all, require an intense collaboration between different areas. The interactions between cortical regions and with subcortical regions such as the cerebellum and basal ganglia are considered essential for proper performance in sensory, motor, and cognitive tasks. It is the capacity and the importance of these interactions that will be studied in this research programme, using the latest methods of measurement and analysis in network activity in the brain. The interactions between the cerebellum, basal ganglia, and cerebral cortex are at the source of our controlled, calibrated actions. The electrical activity recorded with multiple single electrodes, such as action potentials and local field potentials, will be compared for the awake attentive rat and during sensorimotor tasks. A principal objective will be to evaluate if neuronal activity is structured by local influences such as oscillations, and if those promote communication across different areas such as the cerebellum, the basal ganglia, and the cerebral cortex. These patterns of interrelations will be evaluated in and out of tasks, and also with regard to the stability of the circuits during learning of sensorimotor tasks.

许多大脑功能，如果不是全部的话，都需要不同区域之间的密切合作。皮质区域之间以及与皮质下区域（如小脑和基底神经节）之间的相互作用被认为是在感觉、运动和认知任务中正确执行的必要条件。这是能力和这些相互作用的重要性，将在本研究计划中进行研究，使用最新的测量和分析方法在网络活动的大脑。小脑、基底神经节和大脑皮层之间的相互作用是我们控制、校准行动的源泉。将比较清醒注意大鼠和感觉运动任务期间用多个单电极记录的电活动，如动作电位和局部场电位。一个主要目标是评估神经元活动是否由局部影响（如振荡）构成，以及这些影响是否促进了不同区域（如小脑、基底神经节和大脑皮层）之间的通信。这些相互关系的模式将在任务中和任务外进行评估，并在感觉运动任务的学习过程中对电路的稳定性进行评估。