Neurophysiology of cerebellar, striatial, and cerebral oscillations and communication for motor execution and learning

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Many brain functions, if not all, require an intense collaboration between different areas. The interactions between cortical regions and with subcortical regions such as the cerebellum and basal ganglia are considered essential for proper performance in sensory, motor, and cognitive tasks. It is the capacity and the importance of these interactions that will be studied in this research programme, using the latest methods of measurement and analysis in network activity in the brain. The interactions between the cerebellum, basal ganglia, and cerebral cortex are at the source of our controlled, calibrated actions. The electrical activity recorded with multiple single electrodes, such as action potentials and local field potentials, will be compared for the awake attentive rat and during sensorimotor tasks. A principal objective will be to evaluate if neuronal activity is structured by local influences such as oscillations, and if those promote communication across different areas such as the cerebellum, the basal ganglia, and the cerebral cortex. These patterns of interrelations will be evaluated in and out of tasks, and also with regard to the stability of the circuits during learning of sensorimotor tasks.