Roles of native membrane matrix components in regulated secretion

分泌，即储存的化合物的释放，是一个基本的细胞过程，对许多活动至关重要，包括神经系统功能、激素和胰岛素的释放以及伤口愈合。不幸的是，基本的细胞机制尚未完全解决。最后，定义释放步骤本身需要存储室（囊泡）和细胞膜融合，以便室中的内容物可以离开细胞。这一融合步骤的机制及其调控在很大程度上仍未明确。然而，很明显，膜中的脂质和蛋白质成分在自然融合中共同作用。尽管如此，对天然钙触发融合中脂质功能的详细定位和机制研究还没有像蛋白质导向的研究那样有效地进展。

Secretion, the release of stored compounds, is a fundamental cellular process essential for numerous actions including nervous system function, release of hormones and insulin, and wound healing. Unfortunately, the essential cellular machinery has yet to be fully resolved. The final, defining release step itself requires fusion of the storage compartment (vesicle) and the cell membrane, so that the contents of the compartment can leave the cell. The mechanism of this fusion step, and its regulation, remain largely undefined. It is clear however that both lipid and protein components in the membranes act together in native fusion. Nonetheless, detailed mapping and mechanistic studies of lipid functions in native calcium-triggered fusion have not advanced as effectively as have protein-directed studies.