Roles of native membrane matrix components in regulated secretion

天然膜基质成分在调节分泌中的作用

• 批准号: 261972-2008
• 负责人: Coorssen, Jens
• 金额: $ 2.24万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=426887
• 关键词: Roles; native; membrane; matrix; components

Secretion, the release of stored compounds, is a fundamental cellular process essential for numerous actions including nervous system function, release of hormones and insulin, and wound healing. Unfortunately, the essential cellular machinery has yet to be fully resolved. The final, defining release step itself requires fusion of the storage compartment (vesicle) and the cell membrane, so that the contents of the compartment can leave the cell. The mechanism of this fusion step, and its regulation, remain largely undefined. It is clear however that both lipid and protein components in the membranes act together in native fusion. Nonetheless, detailed mapping and mechanistic studies of lipid functions in native calcium-triggered fusion have not advanced as effectively as have protein-directed studies.

分泌，即储存的化合物的释放，是一种基本的细胞过程，对神经系统功能、激素和胰岛素的释放以及伤口愈合等许多活动都是必不可少的。不幸的是，基本的细胞机制还没有完全解决。最后一个明确的释放步骤本身需要储存室(囊泡)和细胞膜的融合，以便储存室的内容物可以离开细胞。这一融合步骤的机制及其调控在很大程度上仍不清楚。然而，很明显，膜中的脂类和蛋白质成分在天然融合中共同作用。尽管如此，对天然钙引发的融合中脂质功能的详细图谱和机制研究并没有像蛋白质指导的研究那样有效地推进。