Integrin-linked kinase in melanosome uptake in keratinocytes

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A key characteristic of animals is their capacity to produce external cutaneous coloration, which is essential for survival, social communication, and protection against damage from solar UV radiation. In mammals, coloration develops through production of melanins by cells called melanocytes, and its transfer to other skin cells termed keratinocytes. The processes whereby melanin is taken up by keratinocytes are not known. We have identified a protein called integrin-linked kinase (ILK) as one of the factors necessary for melanin uptake. Our research will determine how ILK functions during melanin uptake, and how alterations in ILK result in defective melanin transfer and skin or hair coloration.