Integrin-linked kinase in melanosome uptake in keratinocytes

角质形成细胞黑素体摄取中的整合素连接激酶

• 批准号: 261998-2008
• 负责人: Dagnino, Lina
• 金额: $ 2.19万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=426898
• 关键词: Integrin; linked; kinase; melanosome; uptake

A key characteristic of animals is their capacity to produce external cutaneous coloration, which is essential for survival, social communication, and protection against damage from solar UV radiation. In mammals, coloration develops through production of melanins by cells called melanocytes, and its transfer to other skin cells termed keratinocytes. The processes whereby melanin is taken up by keratinocytes are not known. We have identified a protein called integrin-linked kinase (ILK) as one of the factors necessary for melanin uptake. Our research will determine how ILK functions during melanin uptake, and how alterations in ILK result in defective melanin transfer and skin or hair coloration.

动物的一个关键特征是它们产生外部皮肤颜色的能力，这对于生存，社会交流和保护免受太阳紫外线辐射的伤害至关重要。在哺乳动物中，通过称为黑素细胞的细胞产生黑素并将其转移到称为角质形成细胞的其他皮肤细胞来形成颜色。黑色素被角质形成细胞吸收的过程尚不清楚。我们已经确定了一种称为整合素连接激酶（ILK）的蛋白质是黑色素摄取所必需的因子之一。我们的研究将确定ILK在黑色素摄取过程中的功能，以及ILK的改变如何导致黑色素转移和皮肤或头发着色缺陷。