Regulation of MHC class II genes and molecules

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The proposed research program is focused on fundamental molecular mechanisms controlling the expression of Major histocompatibility class II (MHC-II) genes and the intracellular transport of MHC-II molecules. MHC-II molecules serve as antigen presenting molecules for CD4-positive T cells, which play a central role for the adaptive immune response, since they modulate most of the immune reactions, such as activation of B cell, macrophages and CD8-positive cytotoxic T cells. Both MHC-II genes and molecules are subject to multiple levels of control, which are essential for the correct function of the immune response and thus present a very interesting and relevant model system for the study of multi-layered regulatory circuits.