Regulation of MHC class II genes and molecules

MHC II 类基因和分子的调控

• 批准号: 262845-2010
• 负责人: Steimle, Viktor
• 金额: $ 1.97万
• 依托单位: Université de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=525575
• 关键词: Regulation; MHC; class; II; genes

My research program is focused on fundamental molecular mechanisms controlling the expression of Major histocompatibility class II (MHC-II) genes and the intracellular transport of MHC-II molecules. MHC-II molecules serve as antigen presenting molecules for CD4-positive T cells, which play a central role for the adaptive immune response, since they modulate most of the immune reactions, such as activation of B cell, macrophages and CD8-positive cytotoxic T cells. Both MHC-II genes and molecules are subject to multiple levels of control, which are essential for the correct function of the immune response and thus present a very interesting and relevant model system for the study of multi-layered regulatory circuits.

我的研究方向主要集中在控制主要组织相容性类II （MHC-II）基因表达的基本分子机制和MHC-II分子的细胞内转运。MHC-II分子作为cd4阳性T细胞的抗原呈递分子，在适应性免疫反应中起着核心作用，因为它们调节大多数免疫反应，如B细胞、巨噬细胞和cd8阳性细胞毒性T细胞的活化。MHC-II基因和分子都受到多层次的控制，这对于免疫反应的正确功能至关重要，因此为多层调控回路的研究提供了一个非常有趣和相关的模型系统。