Seizures and Carbon Dioxide – a study of respiratory acidosis as a cause for seizure termination and trial of carbogen as an anti-epileptic

癫痫发作和二氧化碳 — 呼吸性酸中毒作为癫痫发作终止原因的研究以及卡波金作为抗癫痫药的试验

• 批准号: nhmrc : 1062538
• 负责人: Dr Saul Mullen
• 金额: $ 21.18万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/seizures-carbon-dioxide-anti-epileptic/455001
• 关键词: Seizures; Carbon; Dioxide; study; respiratory

Although much is known about epilepsy, the reason a seizure stops is not clear. A rise in the acidity of the blood, mainly due to a rise in carbon dioxide from breathing less deeply, may well contribute. Currently the standard treatments given in hospital to stop seizures are sedatives. Although effective, this sedation can need Intensive Care treatment. We aim to develop a safe, rapid, non-sedating way to treat seizures using a small amount of carbon dioxide in oxygen.

虽然对癫痫了解很多，但癫痫发作停止的原因尚不清楚。血液酸度的上升，主要是由于呼吸不深而导致的二氧化碳的上升，很可能是原因之一。目前，在医院给予的标准治疗，以阻止癫痫发作是镇静剂。虽然有效，但这种镇静可能需要重症监护治疗。我们的目标是开发一种安全，快速，非镇静的方法来治疗癫痫发作，使用氧气中的少量二氧化碳。