Inorganometallic chemistry: transformations of phosphorus ligands in transition metal complexes

无机金属化学：过渡金属配合物中磷配体的转化

• 批准号: 288284-2007
• 负责人: Sterenberg, Brian
• 金额: $ 1.82万
• 依托单位: University of Regina
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=395774
• 关键词: Inorganometallic; chemistry; transformations; phosphorus; ligands

The chemistry of phosphorus plays an important role in many different fields. A few of the many industrial applications of phosphorus compounds are fertilizers, pesticides, fire retardants, and detergents. Phosphorus compounds also form a critical part of the energy cycle of cells, among many other biological functions. This proposal involves the development of new techniques for synthesizing compounds of phosphorus. Many important synthetic techniques in organic chemistry involve transition metal complexes. Since the chemistry of phosphorus often resembles that of carbon, techniques involving metal complexes may also be useful for forming phosphorus compounds. We will be developing new techniques for the synthesis of organophosphorus compounds, using transition metal complexes. Metal complexes are useful for stabilizing phosphorus in unusual environments that make it particularly reactive, and thus useful for synthesis. We are interested in phosphido complexes, which have metal phosphorus single bonds, phosphinidenes, which have metal-phosphorus double bonds, and phosphides, which have metal-phosphorus triple bonds. One application of our phosphorus compounds is synthesis of ligands for phosphine-based catalysts. Phosphine catalysts are important in many industries, including the pharmaceutical industry. Other potential applications of our transition-metal phosphorus chemistry include the formation of the building blocks used to make phosphorus-containing polymers, and the formation of new biologically active molecules containing phosphorus.

磷的化学在许多不同的领域中扮演着重要的角色。在磷化合物的许多工业应用中，有几个是化肥、杀虫剂、阻燃剂和洗涤剂。在许多其他生物功能中，磷化合物也是细胞能量循环的关键部分。这项建议涉及开发合成磷化合物的新技术。有机化学中许多重要的合成技术都涉及过渡金属配合物。由于磷的化学成分通常类似于碳的化学成分，因此涉及金属络合物的技术也可能对形成含磷化合物有用。我们将开发利用过渡金属络合物合成有机磷化合物的新技术。金属络合物有助于在特殊环境中稳定磷，使其特别活跃，从而对合成有用。我们对具有金属磷单键的磷络合物、具有金属-磷双键的亚膦化合物和具有金属-磷三键的磷化物感兴趣。我们的磷化合物的一个应用是合成膦催化剂的配体。磷化氢催化剂在许多行业中都很重要，包括制药行业。我们的过渡金属磷化学的其他潜在应用包括形成用于制造含磷聚合物的积木，以及形成新的含有磷的生物活性分子。