Sensitizing tumours to immunotherapy: Development of an RNA-based therapeutic for pancreatic adenocarcinoma that targets the immunosuppressive tumour microenvironment.

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The blood vessels of tumours are highly abnormal resulting in leakiness and hypoxia within the microenvironment. These abnormalities contribute both to the pathology and also to resistance to treatment. We have developed a new drug that is able to inhibit vascular leak, better the response to therapies and improve disease outcome. This work will generate essential data for the development of this drug towards Clinical Trials through interaction with International Pharma.