SETD7-dependent regulation of Hippo/YAP and Wnt/beta-catenin pathways in the intestine

肠道中 Hippo/YAP 和 Wnt/β-catenin 通路的 SETD7 依赖性调节

• 批准号: nhmrc : 1104433
• 金额: $ 41.27万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/setd7-dependent-regulation-pathways-intestine/662749
• 关键词: SETD7; dependent; regulation; Hippo; YAP

Colon cancer accounts for approximately 10% of all cancer-related deaths in Australia. One of the most common causes of colon cancer is a mutation in a signalling pathway called the Wnt/beta-catenin pathway. Despite this knowledge, there are currently no drugs that directly target this pathway to treat colon cancer. We have now identified a new way to control this pathway and have developed a potent and specific drug to block activation of this pathway.

在澳大利亚，结肠癌约占所有癌症相关死亡人数的10%。结肠癌最常见的原因之一是Wnt/ β -连环蛋白信号通路的突变。尽管有这些知识，目前还没有直接针对这一途径治疗结肠癌的药物。我们现在已经确定了一种控制这一途径的新方法，并开发了一种有效的特异性药物来阻断这一途径的激活。