Shedding light onto the structural secrets inside pluripotent stem cells in real-time

实时揭示多能干细胞内部的结构秘密

• 批准号: nhmrc : 2002507
• 金额: $ 55.59万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/shedding-light-structural-real-time/1779912
• 关键词: Shedding; light; onto; structural; secrets

To meet the challenges of life, a human being requires 30 trillion cells, a blue whale a staggering 100 quadrillion. This vast diversity of cells derives from very few unspecialised cells that can become any cell type of the adult body - the pluripotent stem cells. We will use innovative imaging techniques to uncover the cellular architecture of pluripotency to provide critical insights into how the various parts of a versatile cell, its cytoskeleton and organelles, are assembled in real-time.

为了应对生命的挑战，人类需要30万亿个细胞，蓝鲸需要惊人的100万亿个细胞。这种巨大的细胞多样性来源于很少的非特化细胞，这些细胞可以成为成体的任何细胞类型——多能干细胞。我们将使用创新的成像技术来揭示多能性的细胞结构，以提供对多功能细胞的各个部分（其细胞骨架和细胞器）如何实时组装的关键见解。