Voltage-gated Na+ channels in neuronal development
神经元发育中的电压门控Na通道
基本信息
- 批准号:326943-2006
- 负责人:
- 金额:$ 3.1万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2008
- 资助国家:加拿大
- 起止时间:2008-01-01 至 2009-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Mice that have a mutation in Scn8a, a gene that encodes a voltage-gated sodium channel, are blind according to electroretinogram (ERG) recordings (Côté et al. 2005 J Neurosci 25:5046-50). Interestingly, the blindness originates at the level of the photoreceptors, the cells of the retina that initially capture light. This observation is puzzling for two reasons 1) photoreceptors are known to use graded 'analog'-type signals to convey information to other cells while Scn8a is involved in the production and propagation of action potentials (all-or-nothing 'binary'-type signals), 2) the expression of Scn8a in photoreceptors is very weak. For these reasons, we favor the hypothesis that other cell types in the retina that strongly express Scn8a need to communicate directly or indirectly with the photoreceptors during a critical period of development. The long-term goal of the proposed research program is to uncover the cellular pathways that link Scn8a and photoreceptor function and to determine how VGSCs are involved in the maturation of other neural cell types. Knowledge gained on the normal development of the retina and the nervous system during the course of this research program will aid in devising strategies to promote regeneration in states of trauma and to counter degenerative diseases.
根据视网膜电图(ERG)记录,Scn8a基因(一种编码电压门控钠通道的基因)发生突变的小鼠是失明的(Côté et al. 2005 J Neurosci 25:50 06 -50)。有趣的是,失明源于感光细胞的水平,感光细胞是视网膜上最初捕捉光线的细胞。这一观察结果令人困惑,原因有两个:1)已知光感受器使用分级的“模拟”型信号向其他细胞传递信息,而Scn8a参与动作电位的产生和传播(全有或全无的“二元”型信号);2)Scn8a在光感受器中的表达非常微弱。基于这些原因,我们支持这样的假设,即在发育的关键时期,视网膜中其他强烈表达Scn8a的细胞类型需要直接或间接地与光感受器交流。该研究计划的长期目标是揭示连接Scn8a和光感受器功能的细胞途径,并确定VGSCs如何参与其他神经细胞类型的成熟。在这个研究项目的过程中获得的关于视网膜和神经系统正常发育的知识将有助于制定促进创伤状态下的再生和对抗退行性疾病的策略。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Côté, Patrice其他文献
Côté, Patrice的其他文献
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{{ truncateString('Côté, Patrice', 18)}}的其他基金
Influence of Voltage Gated Sodium Channels on Cellular Motility and Inflammation
电压门控钠通道对细胞运动和炎症的影响
- 批准号:
RGPIN-2021-03532 - 财政年份:2022
- 资助金额:
$ 3.1万 - 项目类别:
Discovery Grants Program - Individual
Influence of Voltage Gated Sodium Channels on Cellular Motility and Inflammation
电压门控钠通道对细胞运动和炎症的影响
- 批准号:
RGPIN-2021-03532 - 财政年份:2021
- 资助金额:
$ 3.1万 - 项目类别:
Discovery Grants Program - Individual
Voltage-gated Na+ channels in neuronal development
神经元发育中的电压门控Na通道
- 批准号:
326943-2006 - 财政年份:2010
- 资助金额:
$ 3.1万 - 项目类别:
Discovery Grants Program - Individual
Voltage-gated Na+ channels in neuronal development
神经元发育中的电压门控Na通道
- 批准号:
326943-2006 - 财政年份:2009
- 资助金额:
$ 3.1万 - 项目类别:
Discovery Grants Program - Individual
Voltage-gated Na+ channels in neuronal development
神经元发育中的电压门控Na通道
- 批准号:
326943-2006 - 财政年份:2007
- 资助金额:
$ 3.1万 - 项目类别:
Discovery Grants Program - Individual
Voltage-gated Na+ channels in neuronal development
神经元发育中的电压门控Na通道
- 批准号:
326943-2006 - 财政年份:2006
- 资助金额:
$ 3.1万 - 项目类别:
Discovery Grants Program - Individual
Request for a refrigerated microtome (cryostat)
请求冷冻切片机(低温切片机)
- 批准号:
330030-2006 - 财政年份:2005
- 资助金额:
$ 3.1万 - 项目类别:
Research Tools and Instruments - Category 1 (<$150,000)
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