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Silent Mutations in the HIV-1 Reverse Transcriptase Selected during Antiretroviral Therapy

Silent Mutations in the HIV-1 Reverse Transcriptase Selected during Antiretroviral Therapy
抗逆转录病毒治疗期间选择的 HIV-1 逆转录酶的沉默突变
批准号:
nhmrc : 603704
负责人:
A/Pr Nicolas Sluis-Cremer
金额:
$37.03万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2012-12-31

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中文摘要
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英文摘要
This project seeks to determine the role of silent mutations in the HIV reverse transcriptase that are selected during drug therapy in HIV infected individuals on HIV fitness, reverse transcriptase function and the emergence of drug resistance. This study will increase our understanding of the mechanisms by which the virus evades the effects of antiretrovirals and will provide a rationale for deciding on the best drug combinations for use in patients infected with specific HIV strains (clades).
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会议论文
Targeting novel sites on reverse transcriptase for HIV treatment and prevention
  • 批准号:
    nhmrc : GNT1119940
  • 项目类别:
    Project Grants
  • 资助金额:
    $97.9万
  • 财政年份:
    2017
  • 负责人:
    A/Pr Nicolas Sluis-Cremer
  • 依托单位:
Targeting novel sites on reverse transcriptase for HIV treatment and prevention
Towards a new class of reverse transcriptase inhibitor for HIV prevention
Drug resistance mutations in the connection subdomain of the HIV-1 reverse transcriptase
国内基金
海外基金
DelineatingthemolecularmechanismsunderlyingmammaryepithelialcellcarcinogenesisinpatientswithinheritedBRCA1andBRCA2mutations
  • 批准号:
    --
  • 项目类别:
    --
  • 资助金额:
    160万元
  • 批准年份:
    2022
  • 负责人:
    TAKEDA SHUNICHI
  • 依托单位: