Towards a new class of reverse transcriptase inhibitor for HIV prevention

开发用于预防艾滋病毒的新型逆转录酶抑制剂

• 批准号: nhmrc : 1064900
• 负责人: A/Pr Nicolas Sluis-Cremer
• 金额: $ 45.93万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/new-class-reverse-hiv-prevention/455142
• 关键词: Towards; new; class; reverse; transcriptase

There remains an urgent need for new HIV prevention strategies. New HIV drugs that block the virus by distinct ways are needed to prevent transmission of drug resistant HIV. This study seeks to identify very small molecules called “fragments” that bind to previously undiscovered pockets on the HIV reverse transcriptase to stop its function, and that can be used as building blocks to design more potent HIV drugs to be used solely for HIV prevention.

仍然迫切需要新的艾滋病毒预防战略。需要通过不同方式阻断病毒的新的HIV药物来防止耐药HIV的传播。这项研究旨在确定被称为“片段”的非常小的分子，这些分子与HIV逆转录酶上以前未发现的口袋结合以阻止其功能，并且可以用作构建模块来设计更有效的HIV药物，仅用于HIV预防。