Sirtuins and the molecular epidemiology of frailty in older men

Sirtuins 与老年男性衰弱的分子流行病学

• 批准号: nhmrc : 512364
• 负责人: A/Pr Marina Kennerson
• 金额: $ 32.22万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/sirtuins-molecular-epidemiology-older-men/81383
• 关键词: Sirtuins; molecular; epidemiology; frailty; older

People in Australia are living longer and longer and yet little is known about the underlying biology of the ageing process. This project will investigate the role of a number of molecular and cellular factors in the aetiology of frailty in a group of more than 1400 older men who are already participating in the Concord Health and Ageing in Men Project. A particular focus of the project are sirtiuns, a group of enzymes recently found to be associated with longer life in several animal models.

澳大利亚人的寿命越来越长，但人们对衰老过程的潜在生物学知之甚少。该项目将调查一些分子和细胞因子在一组1400多名老年男性中的脆弱病因学中的作用，这些老年男性已经参加了男性健康与老龄化项目。该项目的一个特别重点是sirtiuns，这是一组最近发现与几种动物模型中的长寿有关的酶。