Sirtuins and the molecular epidemiology of frailty in older men

澳大利亚人的寿命越来越长，但人们对衰老过程的潜在生物学知识知之甚少。这个项目将调查一组1400多名老年男性中一些分子和细胞因素在虚弱病因学中的作用，这些老年男性已经参加了协和健康和男性老龄化项目。该项目的一个特别焦点是sirtiuns，这是一组酶，最近在几种动物模型中发现与更长的寿命有关。

People in Australia are living longer and longer and yet little is known about the underlying biology of the ageing process. This project will investigate the role of a number of molecular and cellular factors in the aetiology of frailty in a group of more than 1400 older men who are already participating in the Concord Health and Ageing in Men Project. A particular focus of the project are sirtiuns, a group of enzymes recently found to be associated with longer life in several animal models.