A novel class of udp-glucuronosyltransferase enzymes (UGTs) that control cell metabolism

一类新型 udp-葡萄糖醛酸基转移酶 (UGT) 控制细胞代谢

• 批准号: 342176-2007
• 负责人: Guillemette, Chantal
• 金额: $ 2.19万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=399792
• 关键词: novel; class; udp; glucuronosyltransferase; enzymes

Our research efforts have recently led to the discovery of a novel class of human proteins involved in host defence against toxins and carcinogens from the body. A diversity of other small molecules of both endogenous and exogenous origin such as hormones, dietary components and drugs are also substrates of these proteins. In this research program we propose to characterize the new class of proteins in humans for their role in the control of cell metabolism. Our preliminary findings indicate that these proteins would represent key modulators of metabolism in cells.

我们的研究工作最近导致发现了一类新的人类蛋白质，它们参与宿主对体内毒素和致癌物质的防御。 多种内源性和外源性来源的其他小分子，如激素、饮食成分和药物也是这些蛋白质的底物。在这项研究计划中，我们建议描述人类中新一类蛋白质在控制细胞代谢中的作用。我们的初步研究结果表明，这些蛋白质将代表细胞中代谢的关键调节剂。