A novel class of udp-glucuronosyltransferase enzymes (UGTs) that control cell metabolism

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Our research efforts have recently led to the discovery of a novel class of human proteins involved in host defence against toxins and carcinogens from the body. A diversity of other small molecules of both endogenous and exogenous origin such as hormones, dietary components and drugs are also substrates of these proteins. In this research program we propose to characterize the new class of proteins in humans for their role in the control of cell metabolism. Our preliminary findings indicate that these proteins would represent key modulators of metabolism in cells.