A novel class of udp-glucuronosyltransferase enzymes (UGTs) that control cell metabolism

我们的研究工作最近发现了一类新的人类蛋白质，涉及宿主防御来自身体的毒素和致癌物。来自内源和外源的各种其他小分子，如激素、饮食成分和药物也是这些蛋白质的底物。在这项研究计划中，我们建议对人类中这类新的蛋白质在细胞新陈代谢控制中的作用进行表征。我们的初步发现表明，这些蛋白质将代表细胞新陈代谢的关键调节器。

Our research efforts have recently led to the discovery of a novel class of human proteins involved in host defence against toxins and carcinogens from the body. A diversity of other small molecules of both endogenous and exogenous origin such as hormones, dietary components and drugs are also substrates of these proteins. In this research program we propose to characterize the new class of proteins in humans for their role in the control of cell metabolism. Our preliminary findings indicate that these proteins would represent key modulators of metabolism in cells.