Small molecule Inhibitors of glutathione transferase omega 1-1 (GSTO1-1) for the treatment of inflammatory disease

用于治疗炎症性疾病的谷胱甘肽转移酶 omega 1-1 (GSTO1-1) 小分子抑制剂

• 批准号: nhmrc : GNT1156455
• 金额: $ 73.75万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/small-molecule-inhibitors-inflammatory-disease/1378930
• 关键词: Small; molecule; Inhibitors; glutathione; transferase

In this project we will develop inhibitors of GSTO1-1, an enzyme that is thought to play an important and exacerbating role in acute and life-threatening inflammatory responses such as those involved in sepsis. We will test our novel and improved compounds in vitro, determine pharmacokinetic properties, profile their selectivity, and test them for in vivo efficacy as potential anti-inflammatory candidates for the future treatment of sepsis..

在这个项目中，我们将开发 GSTO1-1 的抑制剂，这种酶被认为在急性和危及生命的炎症反应（例如与败血症有关的炎症反应）中发挥着重要且加剧的作用。我们将在体外测试我们的新型和改进的化合物，确定药代动力学特性，分析它们的选择性，并测试它们作为未来治疗脓毒症的潜在抗炎候选药物的体内功效。