Smoking cessation and bone health: observational and intervention studies in twins and a Quitline population

戒烟和骨骼健康：双胞胎和戒烟热线人群的观察和干预研究

• 批准号: nhmrc : 299968
• 负责人: Dr Catherine Segan
• 金额: $ 42.61万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/smoking-cessation-bone-quitline-population/81662
• 关键词: Smoking; cessation; bone; health; observational

Osteoporosis is a major health problem that causes bones to break (fracture) easily. Many bones are susceptible, with hip fractures being the worst outcome of osteoporosis. They cause pain, disability, require major health interventions (surgery and rehabilitation), lead to death in about 20% of cases, and the overall care of hip fracture patients is very expensive. Osteoporosis is treated to reduce the risk of fractures. The prevention and treatment of osteoporosis should include avoidance of factors known to bring on or worsen the condition. Smokers are known to have an increased risk of osteoporosis and fractures. However, it is not known how smoking brings on osteoporosis. Importantly, neither is it clear whether quitting smoking leads to improved bone health (and a reduced risk of fractures). These are important questions for the community in general and for smokers with osteoporosis in particular. We will endeavour to answer these questions by studying twins who do and do not smoke and by observing what happens to measures of bone health (bone mineral density and other factors) in people attempting to quit smoking. New information gained from these studies may lead to better ways of avoiding or treating the damage that smoking does to bone. We may also become able to predict the benefit to bone when people quit smoking.

骨质疏松症是一个主要的健康问题，容易导致骨骼断裂(骨折)。许多骨骼易受影响，髋部骨折是骨质疏松症最严重的后果。它们导致疼痛、残疾，需要重大的卫生干预(手术和康复)，导致约20%的病例死亡，髋部骨折患者的整体护理非常昂贵。治疗骨质疏松症是为了降低骨折的风险。预防和治疗骨质疏松症应该包括避免已知会导致或恶化这种情况的因素。众所周知，吸烟者患骨质疏松症和骨折的风险增加。然而，吸烟是如何导致骨质疏松症的尚不清楚。重要的是，目前也不清楚戒烟是否会改善骨骼健康(并降低骨折风险)。对于整个社区，尤其是患有骨质疏松症的吸烟者来说，这些都是重要的问题。我们将努力通过研究吸烟和不吸烟的双胞胎来回答这些问题，并观察试图戒烟的人的骨健康指标(骨密度和其他因素)发生了什么。从这些研究中获得的新信息可能会导致更好的方法来避免或治疗吸烟对骨骼的损害。我们还可以预测人们戒烟对骨骼的益处。