Somatic genomic alterations as predictors of clinical outcomes and benefit from chemohormonal therapy in metastatic hormone sensitive prostate cancer

该项目旨在通过分析患有该疾病的患者的肿瘤基因来更深入地了解晚期和致命性前列腺癌的驱动生物学。通过这样做，我们将能够识别发生在侵袭性前列腺癌中的基因突变，以及它们如何影响对治疗和临床结果的反应。我们也许能够整合这些信息，在未来为患者提供更明智的“精确”护理。

This projects seeks to achieve deeper understanding of the driving biology of advanced and lethal prostate cancer by way of profiling the tumor genes of patients with the disease. By doing so, we will be able to identify the gene mutations that occur in aggressive prostate cancer and how they influence response to treatment and clinical outcomes. We may be able to incorporate this information to deliver more informed, ‘precision’ care to patients in the future.