Sortilin forms a complex with APP and BACE to regulate Abeta production
Sortilin forms a complex with APP and BACE to regulate Abeta production
Sortilin 与 APP 和 BACE 形成复合物来调节 Abeta 的产生
批准号：
nhmrc : 1037776
负责人：
Dr Jia Liu
金额：
$13.93万
依托单位国家：
澳大利亚
项目类别：
Early Career Fellowships
财政年份：
2012
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2012-01-01 至 2014-12-31
中文摘要
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英文摘要
Alzheimer's disease is a neurodegenerative disorder which is highly prevalent in aging population. Amyloid beta is a toxic peptide derived from a metabolic processing of its precursor amyloid precursor protein (APP). This project will examine how a novel protein called sortilin interacts with APP and its processing enzyme and how the toxic peptide is produced. Understanding the trafficking of APP and beta-secretase ?BACE? regulated by sortilin may help understanding how Alzheimer's disease is developed.
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