Sortilin forms a complex with APP and BACE to regulate Abeta production

Sortilin 与 APP 和 BACE 形成复合物来调节 Abeta 的产生

• 批准号: nhmrc : 1037776
• 负责人: Dr Jia Liu
• 金额: $ 13.93万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/sortilin-forms-complex-abeta-production/111097
• 关键词: Sortilin; forms; complex; APP; BACE

Alzheimer's disease is a neurodegenerative disorder which is highly prevalent in aging population. Amyloid beta is a toxic peptide derived from a metabolic processing of its precursor amyloid precursor protein (APP). This project will examine how a novel protein called sortilin interacts with APP and its processing enzyme and how the toxic peptide is produced. Understanding the trafficking of APP and beta-secretase ?BACE? regulated by sortilin may help understanding how Alzheimer's disease is developed.

阿尔茨海默病是一种神经退行性疾病，在老龄化人群中高度流行。淀粉样β蛋白是一种有毒的多肽，其前体淀粉样前体蛋白(APP)在代谢过程中产生。该项目将研究一种名为山梨素的新型蛋白质如何与APP及其加工酶相互作用，以及毒肽是如何产生的。了解APP和β-分泌酶的贩运？BACE？山梨素的调节可能有助于理解阿尔茨海默病是如何发生的。