Dry powder coating technology for pharmaceutical solid dosage forms

药物固体剂型的干粉包衣技术

• 批准号: 355067-2007
• 负责人: Zhu, Jingxu(Jesse)
• 金额: $ 5.28万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=402394
• 关键词: Dry; powder; coating; technology; pharmaceutical

Coating of pharmaceutical solid dosage forms such as tablets and beads are often required in order to improve product appearance and handle-ability, mask taste/odor, smoothen swallowing; increase patient compliance, protect product from moisture and light, and modify drug release characteristics (enteric or sustained release). However, almost all commercial coating processes are based on liquid coating technology, with which a coating solution/suspension is sprayed onto the solid dosage forms and then the liquid gets evaporated to form a dry coating film on the surface. The most significant

通常需要包衣药物固体剂型，如片剂和丸剂，以改善产品外观和处理能力，掩盖味道/气味，平滑吞咽；提高患者依从性，保护产品免受湿气和光照，并改变药物释放特性（肠溶或缓释）。然而，几乎所有的商业涂层工艺都是基于液体涂层技术，将涂层溶液/悬浮液喷洒到固体剂型上，然后将液体蒸发，在表面形成干燥的涂层膜。最重要的