Dissecting the heterogeniety of human tissue-resident memory T cells

组织驻留记忆T细胞(TRM)是抵抗感染和癌症的免疫保护的关键，但TRM功能障碍会导致自身免疫性疾病。虽然我们对TRM的大部分了解来自动物模型，但这些细胞在人类中是如何工作的在很大程度上是未知的。该项目旨在利用一种独特的人体器官捐赠者组织资源，确定人类TRM亚群在肠道、肝脏和皮肤等器官中的表型、功能和调节的异质性。预期的结果是产生基本的新知识，这些知识将对开发针对传染病、癌症和自身免疫的新疗法具有重要意义。

Tissue-resident memory T cells (TRM) are key to immune protection against infection and cancer, yet dysfunctional TRM cause autoimmune disease. Whilst much of our understanding of TRM comes from animal models, how these cells work in humans is largely unknown. This project aims to define the phenotypic, functional and regulatory heterogeneity of human TRM subsets in organs like the gut, liver, and skin using a unique human organ donor tissue resource. The expected outcomes are to generate fundamental new knowledge that will have significance for the development of new therapies against infectious diseases, cancer and autoimmunity.