Stratification of Therapies in HNSCC Through Discovery of Molecular Signatures

通过分子特征的发现对 HNSCC 的治疗进行分层

• 批准号: nhmrc : 1106697
• 负责人: Dr Charbel Darido
• 金额: $ 58.67万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/stratification-therapies-hnscc-molecular-signatures/662929
• 关键词: Stratification; Therapies; HNSCC; Through; Discovery

Human head and neck cancer is a devastating disease with poor survival rates. Using a unique mouse model, we have now uncovered novel genetic defects that trigger cancer development. These defects are also evident in human cancers. This proposal will utilize this mouse model to explore new treatment strategies based on targeting the genetic defect. Ultimately we anticipate that this will translate into personalized therapies that will favourably alter the course of this cancer.

人类头颈癌是一种生存率很低的毁灭性疾病。使用一种独特的小鼠模型，我们现在已经发现了引发癌症发展的新的遗传缺陷。这些缺陷在人类癌症中也很明显。该提案将利用这种小鼠模型来探索基于靶向遗传缺陷的新治疗策略。最终，我们预计这将转化为个性化治疗，这将有利于改变这种癌症的进程。