Stratification of Therapies in HNSCC Through Discovery of Molecular Signatures

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Human head and neck cancer is a devastating disease with poor survival rates. Using a unique mouse model, we have now uncovered novel genetic defects that trigger cancer development. These defects are also evident in human cancers. This proposal will utilize this mouse model to explore new treatment strategies based on targeting the genetic defect. Ultimately we anticipate that this will translate into personalized therapies that will favourably alter the course of this cancer.