Translating molecular insights in Squamous Cell Carcinoma into novel therapeutics

将鳞状细胞癌的分子见解转化为新疗法

• 批准号: nhmrc : 1049870
• 负责人: Dr Charbel Darido
• 金额: $ 57.31万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/translating-molecular-insights-novel-therapeutics/112118
• 关键词: Translating; molecular; insights; Squamous; Cell

In Australia, skin cancers account for 80% of all new cases of cancer, and over 95% of these are basal cell cancers (BCC) or squamous cell cancers (SCC). Although exposure to the sun is the major factor responsible for both of these cancers, it is not known what genes are damaged allowing them to grow in an uncontrolled manner. Our laboratory has identified critical genes that malfunction in SCC. This discovery will allow us to develop new preventative and curative strategies for SCC.

在澳大利亚，皮肤癌占所有新发癌症病例的80%，其中95%以上是基底细胞癌（BCC）或鳞状细胞癌（SCC）。虽然暴露在阳光下是导致这两种癌症的主要因素，但目前尚不清楚是什么基因受损，导致它们以不受控制的方式生长。我们的实验室已经确定了SCC中发生功能障碍的关键基因。这一发现将使我们能够为SCC开发新的预防和治疗策略。