Structural and biochemical investigation of the Bloom�s complex, defective in Bloom�s Syndrome

布卢姆综合征是一种罕见的遗传性疾病，导致25岁时患癌症的风险超过90%。导致布卢姆综合征的基因，称为BLM，保护细胞免受致癌突变的影响，因此受影响的个体会发展出与普通人群相同类型的癌症，只是速度更快。我们将研究BLM基因产物的特性，了解它如何保护我们免受癌症的侵害，并可能影响某些形式的癌症治疗。

Bloom�s Syndrome is a rare inherited disorder that results in greater than 90% risk of developing cancer by the age of 25. The gene that causes Bloom�s Syndrome, called BLM, protects cells from cancer-causing mutations hence affected individuals develop the same types of cancers as the general population, only much faster. We will investigate the properties of the BLM gene product and understand how it protects us from cancer, and may influence some forms of cancer treatment.