Biochemical reconstitution of the ubiquitin ligase pathway defective in Fanconi Anaemia

范可尼贫血（FA）的特点是重要的血细胞损失，但也有700倍的风险发展为白血病和其他癌症。FA是由15种不同基因中的一种遗传缺陷引起的，这些基因提供了一种信号和修复机制，保护细胞免受致癌突变的影响。通过在试管中重建这种信号传导机制，我们将确定它如何有助于癌症保护，并强调在一般人群中治疗FA和白血病的潜在策略。

Fanconi Anemia (FA) is characterised by loss of vital blood cells but also 700x risk of developing leukaemia and other cancers. FA is caused by an inherited defect in one of 15 different genes that provide a signal and repair mechanism protecting cells from cancer causing mutations. By reconstructing this signaling mechanism in the test tube we will determine how it contributes to cancer protection, and highlight potential strategies for treatment of FA and leukaemia in the general population.