Biochemical investigation of ubiquitination by the Fanconi anaemia pathway
Biochemical investigation of ubiquitination by the Fanconi anaemia pathway
批准号:
nhmrc : 1123100
负责人:
Dr Andrew Deans
金额:
$41.18万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 2019-12-31
中文摘要
范可尼贫血是一种遗传性疾病,患白血病和癌症的风险大大增加。致病基因是“肿瘤抑制因子”,通过修复DNA损伤的复杂功能保护我们免受癌症的侵害。这项研究旨在了解这种DNA修复功能如何保护我们免受癌症的侵害,并可能影响某些形式的新癌症治疗。
英文摘要
Fanconi anaemia is an inherited disorder with greatly elevated risk of leukaemia and cancers. The causal genes are ‘tumour suppressors’ that protect us from cancer by a complex function in repair of damage to our DNA. This study aims to understand how this DNA repair function protects us from cancer, and may influence some forms of new forms of cancer treatment.
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会议论文
Biochemical reconstitution of the ubiquitin ligase pathway defective in Fanconi Anaemia
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批准号:nhmrc : 1031104
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项目类别:Project Grants
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资助金额:$37.52万
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财政年份:2012
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负责人:Dr Andrew Deans
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依托单位:
Structural and biochemical investigation of the Bloom�s complex, defective in Bloom�s Syndrome
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批准号:nhmrc : 1033592
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项目类别:NHMRC Project Grants
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资助金额:$12.31万
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财政年份:2012
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负责人:Dr Andrew Deans
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依托单位:
Identification of novel DNA recombination-repair factors
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批准号:nhmrc : 448334
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项目类别:Early Career Fellowships
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资助金额:$20.44万
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财政年份:2007
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负责人:Dr Andrew Deans
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依托单位:
海外基金