Biochemical investigation of ubiquitination by the Fanconi anaemia pathway

范可尼贫血途径泛素化的生化研究

• 批准号: nhmrc : 1123100
• 负责人: Dr Andrew Deans
• 金额: $ 41.18万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/biochemical-investigation-ubiquitination-anaemia-pathway/947095
• 关键词: Biochemical; investigation; ubiquitination; Fanconi; anaemia

Fanconi anaemia is an inherited disorder with greatly elevated risk of leukaemia and cancers. The causal genes are ‘tumour suppressors’ that protect us from cancer by a complex function in repair of damage to our DNA. This study aims to understand how this DNA repair function protects us from cancer, and may influence some forms of new forms of cancer treatment.

范可尼贫血是一种遗传性疾病，患白血病和癌症的风险大大增加。致病基因是“肿瘤抑制因子”，通过修复 DNA 损伤的复杂功能来保护我们免受癌症的侵害。这项研究旨在了解这种 DNA 修复功能如何保护我们免受癌症的侵害，并可能影响某些新形式的癌症治疗。