Structural investigations of the Bax and Bak cell death apparatus

Bax 和 Bak 细胞死亡装置的结构研究

• 批准号: nhmrc : 1023055
• 负责人: A/Pr Peter Czabotar
• 金额: $ 18.37万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-investigations-bax-death-apparatus/110239
• 关键词: Structural; investigations; Bax; Bak; cell

Programmed cell death is a process by which the body keeps rogue cells in check. Cancer cells adapt to avoid this process and thus evade this important defence mechanism. This project seeks to understand the machinery that controls programmed cell death at the molecular level. It will provide the atomic details of how this machinery is regulated and how it functions to induce cell death. These insights will provide new avenues for targeting this machinery for a new generation of cancer therapeutics.

程序性细胞死亡是机体控制不良细胞的一个过程。癌细胞适应以避免这一过程，从而逃避这一重要的防御机制。该项目旨在了解在分子水平上控制程序性细胞死亡的机制。它将提供这种机制是如何被调控的原子细节，以及它是如何起作用诱导细胞死亡的。这些见解将为针对这一机制的新一代癌症治疗提供新的途径。