Structural Basis for Restraint and Activation of Pro-apoptotic Bax and Bak

抑制和激活促凋亡 Bax 和 Bak 的结构基础

• 批准号: nhmrc : 575561
• 负责人: A/Pr Peter Czabotar
• 金额: $ 16.44万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-basis-restraint-bax-bak/82706
• 关键词: Structural; Basis; Restraint; Activation; Pro

The aim of this project is to understand how cell death is controlled. Defects in the cell death machinery occur in many cancers, making that machinery an attractive target for cancer therapeutics. My experiments will yield atomic resolution pictures of the functional machinery, illustrating for the first time how the molecular brakes are applied to prevent cells dying. Understanding these structures will aid the discovery of drugs that can activate the cell death machinery in cancer cells.

这个项目的目的是了解细胞死亡是如何控制的。细胞死亡机制的缺陷发生在许多癌症中，使这种机制成为癌症治疗的一个有吸引力的目标。我的实验将产生功能机制的原子分辨率图片，首次说明如何应用分子制动器来防止细胞死亡。了解这些结构将有助于发现能够激活癌细胞中细胞死亡机制的药物。