Structural investigations of the Bcl-2 family cell death apparatus

Bcl-2家族细胞死亡装置的结构研究

• 批准号: nhmrc : 1079706
• 负责人: A/Pr Peter Czabotar
• 金额: $ 40.85万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-investigations-bcl-death-apparatus/518693
• 关键词: Structural; investigations; Bcl; family; cell

Programmed Cell Death is a process by which dangerous cells are removed from the body. Sometimes it goes wrong and causes disease, e.g. cancer cells stay alive when they should die. This project will study a group of proteins that regulate cell death, the Bcl-2 family of proteins, in order to understand the mechanism by which they control the balance of cell life and death. The findings will inform the development of new drugs aimed at regulating cell death in a variety of disease states.

程序性细胞死亡是一种将危险细胞从体内清除的过程。有时它出了问题，导致疾病，例如，癌细胞在应该死亡的时候还活着。该项目将研究一组调节细胞死亡的蛋白质，即Bcl-2蛋白家族，以了解它们控制细胞生与死平衡的机制。这一发现将为开发旨在调节各种疾病状态下细胞死亡的新药提供信息。