A structural investigation into the T-cell response to Epstein Barr Virus infection

X射线结晶学是解决蛋白质三维结构的重要工具。蛋白质控制细胞内的生物过程，而蛋白质的精确形状决定了它们的功能。根据氨基酸的特定序列，蛋白质分子会弯曲，形成独特的复杂形状。氨基酸是蛋白质的构建单位。这种特殊的三维形状允许蛋白质承担其特定的功能，如与其他蛋白质结合、作为酶或与核酸相互作用。为了确定蛋白质的行为，在原子水平上知道精确的三维形状是至关重要的。这项建议涉及了解控制对Epstein Barr病毒的免疫反应的蛋白质的准确形状。爱泼斯坦-巴尔病毒是一种普遍存在的人类病原体，与许多癌症有关。这项工作将进一步加深我们对Epstein Barr病毒免疫应答的理解。

X-ray crystallography is an essential tool for solving the three-dimensional structure of proteins. Proteins control the biological processes within the cell and it is the precise shape of proteins that determines how they function. Depending on the particular sequence of the amino acids, the so-called building unit of the proteins, the protein molecule bends and forms a distinct, complex shape. This specific three-dimensional shape allows the protein to undertake its specific function, such as binding to other proteins, acting as an enzyme or interacting with nucleic acids. To determine how a protein acts, it is vital to know the precise three-dimensional shape at the atomic level. This proposal is concerned with understanding the precise shape of proteins that control the immune response to Epstein Barr Virus. Epstein Barr Virus is an ubiquitous human pathogen that has being linked to a number of cancers. This work will further our understanding of the immune response to Epstein Barr Virus.