Structural and mechanical determinants of airway hyperresponsiveness

气道高反应性的结构和机械决定因素

• 批准号: nhmrc : 1045824
• 负责人: Dr Peter Noble
• 金额: $ 27.69万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-mechanical-determinants-airway-hyperresponsiveness/111791
• 关键词: Structural; mechanical; determinants; airway; hyperresponsiveness

In asthma and chronic obstructive pulmonary disease, the capacity for airway passages to narrow is increased which limits airflow in and out of the lung and contributes to disease severity. The aim of this project is to identify the underlying physiological abnormalities producing the increased narrowing capacity. The investigations will focus on the role of the airway smooth muscle and epithelial layers that are widely implicated in driving the increased narrowing response, but for which the evidence remains circumstantial.

在哮喘和慢性阻塞性肺病中，气道通道变窄的能力增加，这限制了进出肺部的气流，并导致疾病的严重程度。该项目的目的是确定潜在的生理异常产生的变窄能力增加。研究将集中在气道平滑肌和上皮层的作用，它们广泛涉及驱动狭窄反应的增加，但证据仍然是间接的。