Regulation of pulmonary responsiveness by chronic mechanical strain and its role in obstructive lung disease

慢性机械应变对肺反应性的调节及其在阻塞性肺疾病中的作用

• 批准号: nhmrc : 513921
• 负责人: Dr Peter Noble
• 金额: $ 19.16万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-pulmonary-responsiveness-lung-disease/115662
• 关键词: Regulation; pulmonary; responsiveness; chronic; mechanical

The pressures required to breathe place a continuous but varying mechanical strain on airway passages and lung tissue. This mechanical strain may protect the airway from collapsing, however, this protection is deficient in lung diseases such as asthma. This project considers the possibility that abnormal mechanical strain occurring in lung disease predisposes the individual to debilitating and potentially life-threatening airflow obstruction.

呼吸所需的压力在气道通道和肺组织上施加连续但变化的机械应变。这种机械应变可以保护气道免于塌陷，然而，这种保护在肺部疾病如哮喘中是不足的。该项目考虑了在肺部疾病中发生的异常机械应变使个体易于衰弱和潜在危及生命的气流阻塞的可能性。