Impact of the COVID-19 pandemic, SARS-CoV-2 infection and social determinants of health on pregnancy complications, birth outcomes and post-pregnancy maternal cardiovascular and mortality outcomes

COVID-19 大流行、SARS-CoV-2 感染和健康社会决定因素对妊娠并发症、出生结局以及孕后孕产妇心血管和死亡率结局的影响

基本信息

  • 批准号:
    10598574
  • 负责人:
  • 金额:
    $ 49.47万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-04-01 至 2025-03-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Nationally, South Carolina (SC) ranks among the worst for poor pregnancy outcomes and high maternal and infant mortality rates, with vast racial/ethnic disparities present. Infection with the novel SARS-CoV-2 during pregnancy has been associated with pregnancy complications and poor infant and maternal outcomes including mortality. Moreover, the effect of social determinants and inequities in healthcare received and health outcomes have been heightened by the COVID-19 pandemic caused by SARS-CoV-2. Cardiovascular risk factors during pregnancy (e.g., obesity, diabetes, and hypertension) and pregnancy complications such as pre-eclampsia are common, can result in morbidity and mortality for the mother and the baby, and are well-known risk factors for maternal cardiovascular and vascular disease short and long-term. Infection with SARS-CoV-2 during pregnancy has also been related to complications (e.g., intensive care unit (ICU) admission, invasive ventilation, myocardial infarction, embolism). Less information is available regarding the impact of the COVID-19 pandemic or specifically SARS-CoV-2 infection on maternal and infant morbidity and mortality. The objective of our study is to understand the impact of both the COVID-19 pandemic and infection with SARS-CoV-2 on the risk of maternal and infant morbidity and mortality including pregnancy complications (e.g., pre-eclampsia, ICU admissions, mechanical ventilation), adverse birth outcomes (e.g., preterm birth, small for gestational age), and maternal cardiovascular events (e.g., coronary heart disease, stroke, embolism) during and post-pregnancy. Data from statewide administrative datasets (e.g., hospitalizations, vital records, Medicaid, positive COVID-19 tests) will be linked to create a diverse, longitudinal cohort of women who gave birth between 2018-2021 with at least one year of follow-up through 2022. Approximately 45,000 live birth pregnancies take place in SC each year for a total of ~180,000 deliveries anticipated over the 4-year study period. As of June 1, 2021, 2600 pregnant women in SC were diagnosed with COVID-19. The proposed project aims to evaluate the impact of the COVID-19 pandemic (Aim 1) and the impact of SARS-CoV-2 infection (Aim 2) at the population level in SC on (1) pregnancy complications, adverse birth outcomes, maternal cardiovascular events, and maternal and infant mortality; (2) maternal one-year post pregnancy cardiovascular and mortality outcomes; and (3) to examine differences by race/ethnicity, social vulnerability, distance to main medical facility, and pre-pregnancy obesity and diabetes. This study will be among the first to evaluate the COVID-19 pandemic and SARS-CoV-2 infection during pregnancy in relation to maternal and infant morbidity and mortality in a population-based study. Determining the impact of the COVID-19 pandemic and SARS-CoV-2 infection on infant and maternal morbidity and mortality and the extent of social and racial-ethnic differences is critical to improving pregnancy outcomes and health disparities in the U.S. Findings are expected to inform clinical care of pregnant women and public health policy.
项目总结

项目成果

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KELLY J HUNT其他文献

KELLY J HUNT的其他文献

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{{ truncateString('KELLY J HUNT', 18)}}的其他基金

Examining linkages between disrupted care and chronic disease outcomes during the COVID-19 pandemic: a VAMC level spatio-temporal analysis
检查 COVID-19 大流行期间中断的护理与慢性病结果之间的联系:VAMC 级别时空分析
  • 批准号:
    10641136
  • 财政年份:
    2023
  • 资助金额:
    $ 49.47万
  • 项目类别:
A South Carolina ECHO Pregnancy Cohort
南卡罗来纳州 ECHO 妊娠队列
  • 批准号:
    10746617
  • 财政年份:
    2023
  • 资助金额:
    $ 49.47万
  • 项目类别:
Impact of the COVID-19 pandemic, SARS-CoV-2 infection and social determinants of health on pregnancy complications, birth outcomes and post-pregnancy maternal cardiovascular and mortality outcomes Div
COVID-19 大流行、SARS-CoV-2 感染和健康社会决定因素对妊娠并发症、出生结局以及孕后孕产妇心血管和死亡率结果的影响 Div
  • 批准号:
    10732644
  • 财政年份:
    2022
  • 资助金额:
    $ 49.47万
  • 项目类别:
Impact of the COVID-19 pandemic, SARS-CoV-2 infection and social determinants of health on pregnancy complications, birth outcomes and post-pregnancy maternal cardiovascular and mortality outcomes
COVID-19 大流行、SARS-CoV-2 感染和健康社会决定因素对妊娠并发症、出生结局以及孕后孕产妇心血管和死亡率结局的影响
  • 批准号:
    10467634
  • 财政年份:
    2022
  • 资助金额:
    $ 49.47万
  • 项目类别:
Impact of neighborhood and workforce deprivation on diabetes outcomes in Veterans: a spatio-temporal analysis
社区和劳动力匮乏对退伍军人糖尿病结局的影响:时空分析
  • 批准号:
    10186523
  • 财政年份:
    2018
  • 资助金额:
    $ 49.47万
  • 项目类别:
Impact of neighborhood and workforce deprivation on diabetes outcomes in Veterans: a spatio-temporal analysis
社区和劳动力匮乏对退伍军人糖尿病结局的影响:时空分析
  • 批准号:
    9904151
  • 财政年份:
    2018
  • 资助金额:
    $ 49.47万
  • 项目类别:
Impact of neighborhood and workforce deprivation on diabetes outcomes in Veterans: a spatio-temporal analysis
社区和劳动力匮乏对退伍军人糖尿病结局的影响:时空分析
  • 批准号:
    9503218
  • 财政年份:
    2018
  • 资助金额:
    $ 49.47万
  • 项目类别:
Exposome Contributors to Child Health Originating from National Fetal Growth Study (ECCHO-NFGS)
源自国家胎儿生长研究 (ECCHO-NFGS) 的暴露组对儿童健康的贡献
  • 批准号:
    9355740
  • 财政年份:
    2016
  • 资助金额:
    $ 49.47万
  • 项目类别:
Longitudinal Assessment of LDL Immune Complexes and Type 1 Diabetes Complications
LDL 免疫复合物和 1 型糖尿病并发症的纵向评估
  • 批准号:
    8092481
  • 财政年份:
    2010
  • 资助金额:
    $ 49.47万
  • 项目类别:
Longitudinal Assessment of LDL Immune Complexes and Type 1 Diabetes Complications
LDL 免疫复合物和 1 型糖尿病并发症的纵向评估
  • 批准号:
    7949257
  • 财政年份:
    2010
  • 资助金额:
    $ 49.47万
  • 项目类别:
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