Structure and Function of Receptors for IgG (FcgammaR)

IgG 受体 (FcgammaR) 的结构和功能

• 批准号: nhmrc : 488405
• 负责人: Dr Bruce Wines
• 金额: $ 51.5万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structure-function-receptors-igg-fcgammar/100764
• 关键词: Structure; Function; Receptors; IgG; FcgammaR

We are investigating one of the most important receptor families of inflammatory white blood cells - so called Fc receptors. These are critically important in resistance to infection. Unfortunately they are also crucial in tissue destruction in autoimmune diseases such as rheumatoid arthritis. We will determine how these receptors trigger inflammation and use this information for the development of new drugs to treat rheumatoid arthritis and lupus.

我们正在研究炎症性白色血细胞最重要的受体家族之一--所谓的Fc受体。这些对于抵抗感染至关重要。不幸的是，它们在自身免疫性疾病如类风湿性关节炎的组织破坏中也是至关重要的。我们将确定这些受体如何触发炎症，并利用这些信息开发治疗类风湿性关节炎和狼疮的新药。