Structure and function of receptors for IgG (FcgammaR)

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We are studying one of the most important receptor families of inflammatory white blood cells, so called Fc receptors. These are crucially important in maintaining resistance to infection. Unfortunately they are also instrumental in causing tissue damage in major inflammatory diseases including arthritis, lupus and bleeding disorders. Our studies of how Fc receptors trigger inflammation will provide the basis for the development of new drugs and strategies to treat chronic inflammation.