Structure and function of receptors for IgG (FcgammaR)

IgG 受体 (FcgammaR) 的结构和功能

• 批准号: nhmrc : 1002270
• 负责人: Dr Bruce Wines
• 金额: $ 45.24万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structure-function-receptors-igg-fcgammar/108796
• 关键词: Structure; function; receptors; IgG; FcgammaR

We are studying one of the most important receptor families of inflammatory white blood cells, so called Fc receptors. These are crucially important in maintaining resistance to infection. Unfortunately they are also instrumental in causing tissue damage in major inflammatory diseases including arthritis, lupus and bleeding disorders. Our studies of how Fc receptors trigger inflammation will provide the basis for the development of new drugs and strategies to treat chronic inflammation.

我们正在研究炎性白细胞最重要的受体家族之一，即所谓的Fc受体。这些对于保持对感染的抵抗力至关重要。不幸的是，在包括关节炎、狼疮和出血性疾病在内的主要炎症性疾病中，它们也是造成组织损伤的重要因素。我们对Fc受体如何引发炎症的研究将为开发治疗慢性炎症的新药和策略提供基础。