Fc alpha RI: ligand interaction and membrane organisation.

Fc alpha RI：配体相互作用和膜组织。

• 批准号: nhmrc : 181627
• 负责人: Dr Bruce Wines
• 金额: $ 33.18万
• 依托单位: Victoria University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/fc-alpha-ri-membrane-organisation/94765
• 关键词: Fc; alpha; RI; ligand; interaction

Antibodies tag invading viruses or bacteria thus marking them as foreign and targeting them for destruction by the immune system. In man the most prevelant antibody is IgA and this antibody provides protection from infecton in the blood and in the fluids at the surface of the lungs, gut and urinogenital tract. Once tagged by antibody the invading bacteria or antigen can be recogniseed white blood cells. These workhorses of the immune system use special molecules called Fc receptors on their surface to recognise antibody tags. The receptor for IgA tags is called the Fc alpha receptor. This receptor is essential for the normal IgA-mediated protection against infection. However in a common kidney disease IgA tags accumulate in the glomerulus of the kidney stimulating white blood cells to attack and damage the kidney. This study will explain how the Fc alpha receptor recognises IgA antibody tags. It will investigate how the presentation of different forms of the receptor and different types of IgA antibody tags contributes to immunity to infection. For example one form of the receptor has a fat molecule joined to its end. We believe this may affect where the Fc alpha recptor goes to in the white blood cell membrane and whether it can activate the white blood cell to fight the invading microorganism.

抗体标记入侵的病毒或细菌，从而将它们标记为外来的，并针对它们进行免疫系统的破坏。在人类中，最常见的抗体是IgA，这种抗体可以防止血液以及肺部、肠道和泌尿生殖道表面的液体感染。一旦被抗体标记，入侵的细菌或抗原就可以被白细胞识别。这些免疫系统的主力使用它们表面上称为Fc受体的特殊分子来识别抗体标签。IgA标签的受体被称为Fcα受体。这种受体对于正常的IgA介导的抗感染保护是必不可少的。然而，在一种常见的肾脏疾病中，IgA标签积聚在肾脏的肾小球中，刺激白细胞攻击和损害肾脏。这项研究将解释Fcα受体如何识别IgA抗体标签。它将调查不同形式的受体和不同类型的IgA抗体标签的呈现如何有助于对感染的免疫。例如，一种形式的受体末端连接了一个脂肪分子。我们认为，这可能会影响Fcα受体在白细胞膜上的去向，以及它是否能激活白细胞来对抗入侵的微生物。